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KMID : 1033720170180030162
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Archives of Craniofacial Surgery
2017 Volume.18 No. 3 p.162 ~ p.165
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Does Low-Dose Heparin Have a Significant Role in Free Flap Surgery?
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An Mun-Young
Shin Jin-Yong
Lee Young-Keun
Sabbagh M. Diya
Roh Si-Gyun
Lee Nae-Ho
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Abstract
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Background: It is controversial issue that heparin decreases thrombosis for microsurgical anastomosis, and its effective role is under discussion. This study is for proving whether low-dose heparin is preventing thrombosis in free flap reconstruction.
Methods: Through chart reviews of 134 patients, using low-dose heparin for free tissue transfer from 2011 to 2016, retrospective analysis was performed. 33 patients received low-dose heparin therapy after surgery. And 101 patients received no-heparin therapy. Complications included flap necrosis, hematoma formation, dehiscence and infection.
Results: In no-heparin therapy group, comparing the flap necrosis revealed 16 cases (15.84%). And, flap necrosis was 6 cases (18.18%) in low-dose heparin therapy group. The statistical analysis of flap necrosis rate showed no significant difference (p=0.75). The results showed that there was no significant difference of flap necrosis rate between two groups.
Conclusion: In this study, patients in the low-dose heparin group had no significantly lower rates of flap failure compared with no-heparin group. This suggests that low-dose heparin may not prevent thrombosis and subsequent flap failure to a significant extent.
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KEYWORD
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Heparin, Free tissue flaps, Necrosis, Hematoma
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